Research has shown berberine may help stop fat molecules from growing in a person’s body. It may also help regulate a person’s metabolism. These effects may aid weight loss. Maintaining a healthy weight protects us from heart disease, type 2 diabetes, stroke, osteoarthritis, and certain types of cancer. Berberine may help with weight loss and assist in shrinking belly fat. 
The anti-inflammatory and antimicrobial aspects of berberine may support the gut microbiome of people with gastrointestinal ailments, diarrhea, and bacterial overgrowth due to irritable bowel syndrome, ulcerative colitis, and other inflammatory bowel diseases.
It might help strengthen the heartbeat, which could benefit people with certain heart conditions. It might also kill bacteria, help regulate how the body uses sugar in the blood, and help reduce swelling.